Tag Archives: research

SUBJECTIVITY OF TIME PERCEPTION

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People often acknowledge perceiving time differently across various situations. Common expressions acknowledge some of these experiences. “A watched pot never boils,” reflects upon time slowing down due to anticipation or perhaps increased attentiveness. “Time flies when you are having fun,” reveals the common experience of time speeding up during relaxed and entertaining activities.

But does time perception actually change across different experiences, or do people simply recall these experiences differently? Previous studies have examined how people perceive time across various experiences. Mostly, research has focused on perceived time duration during life-threatening situations; specifically the feeling that time slows to a near halt when a person experiences a perceived threat (Droit-Volet, Brunot, and Niedenthal, 2004)[1].

A new study focused on a divergent experience, attraction. Joana Arantes, a psychologist at the University of Canterbury, looked at the popular belief of “time seem[ing] to slow down, or stop, when [a person] falls in love at first sight.” The idiom, common in film and fiction, may provide an evolutionary advantage for reproduction by creating a more intense recall of an attractive individuals, representing reproductive fitness—or perhaps the experience might provide the observer with more information from which to make a decision.

TIME DURATION AND LOVE AT FIRST SIGHT

The Scalar Expectancy Theory[2] is the leading explanation accommodating for the difference between perceived and actual time. Scalar timing bases perceptions of time on internal mechanisms, a pacemaker-accumulator system. When a person is aroused, such as in life-threatening situations, time seems to slow down because the pacemaker rate increases due to increased awareness and assessment of environmental stimuli. Dr. Arantes believes the timing system may have evolved to enhance reproductive success, and not just to prepare an individual for defensive actions. Her study specifically looked at how women estimate time after viewing an attractive man.

Gabor Disc

A Gabor disc, the neutral stimulus.

The study included twenty-seven female participants. During the experiment, participants were presented with five stimuli. The first four stimuli were considered neutral stimuli, a picture of Gabor discs. Each participant was expected to reproduce the duration of the fifth stimulus, during two two blocks of a 105 trials. In one block, the fifth stimulus could either be another neutral stimulus, a picture of an attractive male, a picture of an unattractive male. In the other block, the fifth stimulus could either be neutral, a picture of an attractive female, or a picture of an unattractive female.  Time duration estimates were measured across the three different conditions for each block. There were seven different stimulus durations, and each condition was measured five times for each duration.

This study seems to confirm the idea that time slows down “with love at first sight.” The perceived time duration significantly increased when the participants were presented with an attractive male stimulus, over all other conditions. The differences between female photos varied only slightly, but did show an overall increased duration over the neutral stimulus

QUESTIONS

Dr. Arantes suggests that reproductive fitness, represented by a photo of an attractive member of the opposite sex, increases arousal, and therefore perceived time. While the methodology presents a strong case for Dr. Arantes’s results, several questions.

  • It is unclear whether the participants found the pictures attractive or unattractive. The pictures were taken from internet sources and rated by 8 female raters. Attractive photos were of models and actors, while unattractive photos were taken from blogs and non-professional websites. Other (biometric?) measures might determine variations of attractiveness, such as observed pupil dilation, or other somatic responses.[3]
  • The study does not clearly relate attractiveness to mate selection, or how it might differ between genders.
  • Will the effects replicate with male participants?
  • What about persons with different sexual orientations? If they experience a similar effect with same-sex individuals, does this alter the idea that arousal and time duration relates to reproductive strengths?
  • How do increased time durations affect reproductive selection?

Dr. Arantes presents a strong, well-constructed case for her theories, but further evidence is needed to determine just how and why (or if) time perception influences “love at first sight.” She has received significant funding to follow up on her initial findings[4]. This funding will hopefully provide Dr. Arantes the opportunity to expand her original research and explore some of the questions propagated by the original study.

 

[1] Droit-Volet, S., Brunot, S., & Niedenthal, P. M. (2004). Perception of duration of emotional events. Cognition and Emotion, 18, 849.

[3] Hamann, S., Herman, R. A., Nolan, C. L., & Wallen, K. (2004). Men and women differe in amygdala response to visual sexual stimuli. Nature Neuroscience, 7(1), 411.

[4] Scoop Media (2013, November 3) UC psychology expoert studying origins of attraction. Scoop Independent News. Retrieved from http://www.scoop.co.nz/stories/ED1311/S00019/uc-psychology-expert-studying-origins-of-attraction.htm

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JOIN THE DISCUSSION!

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/r/getpsyched

/r/getpsychedThere’s a lot going on beneath the surface of GETPSYCHED!

Over the weekend we launched the official GETPSYCHED sub-reddit at (www.reddit.com/r/getpsyched)!

The sub-reddit serves a dual purpose. It will serve as the site’s forum, and an extension of the GETPSYCHED blog, as well as, and independent site, providing different content in addition to content from the main site. The new content will maintain the same narrative of GETPSYCH, examining current psychological research from a science-based perspective.

We encourage criticism of current trends, and articles,  through fair, skeptical debate. Also, subscribers may suggest topics, post their own links for discussion, or ask a question of blog and sub-reddit moderators.

Subscribe today and join the discussion!

RESOURCE-FULNESS

Also, last night we launched the new Resources page for GETPSYCHED!

The Resources page is currently in development, but will serve as a landing page for information utilized by blog posts, with a brief description of the information, and links to other pages hosted on GETPSYCHED.

Blog posts will directly link to various positions on the resource page, in order to provide clarity when discussing various

The first published site information is an explanation of logic, and logical fallacies.

 

STAY TUNED! Check out the new additions, and look for more over the next couple weeks!

FOLLOW @GETPSYCHEDBLOG and keep up on new research, blog posts and now new reddit discussions at /r/getpsyched! 

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A SITE UPDATE / DISCOVERING CONSCIOUSNESS?

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No long post this week. I am taking time to do some site maintenance, add new pages, and clean-up some formatting issues.

 

In the mean time—I do wish to share an interesting study.

 

ScienceDaily recently covered a study revealing connections between consciousness and brain function. Psychologist at UCLA studied brain images in order to discover what happens as we enter an unconscious state.

“It turns out that when we lose consciousness, the communication among areas of the brain becomes extremely inefficient, as if suddenly each area of the brain became very distant from every other, making it difficult for information to travel from one place to another,” Monti said.

 

Their evidence points to consciousness, not as a function housed in any particular location, but as a product of activity and interactions between different areas of the brain.  The traditional theory places the thalamus—the deep, central compact portion of the brain—as the relay center and main component of the conscious mind, relaying signals between the different functional areas of the outer brain, known as cortex. Instead, activity during consciousness seems to flow across and within the various cortex, and the efficiency of the network, and of information processing, affects the functional level of consciousness.

 

What does this mean? It may help neuro-scientists detect the effectiveness of treatments and interventions, by analyzing the functional efficiency of information flowing across the cortical brain. The area requires a lot more research, but the UCLA team seems to have at least discovered an important aspect of the conscious mind.

 

Check out ScienceDaily’s article.

 

STAY TUNED!

Look for NEW posts every MONDAY!

If anyone has topic suggestions, studies, or areas you would like explored with greater depth, contact me via e-mail, twitter, google+—or just leave a comment!

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EXAMINING CBT AS AN EFFECTIVE INSOMNIA THERAPY

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A TALE OF TWO STUDIES

In my previous post[1], I reviewed a study[2] about  acupressure[3]. The researchers attempted to establish acupressure as an effective therapeutic method for the management of psychophysiological insomnia[4]. The study (somehow) concluded acupressure was a “safe, effective and cost-effective therapy,” though the study design didn’t actually test acupressure, or provide a clear, descriptive methodology and data showing the effective management of insomnia in the sample group. The study instead provided presented a causative effect from the research information it collected using the Sea-Band device, even though:

  • No research had even established the efficacy of the device as an acupressure therapy (nor had any science-based research established any meaningful therapeutic effects of acupressure)
  • The study did not directly test the safety of the device
  • The researchers concluded the effectiveness of the device using the presumed authority [5]of a standard sleep study test and quantitative data, in order to dredge for significance across 22 data points from only two data sets, one pre-treatment measurement and one post-“treatment”

The acupressure study left a sour taste in my mouth. It seemed to be an overt attempt to provide legitimacy to Eastern “medicine,” acupressure, and the Sea-Band device by masking a poorly designed, poorly implemented pseudoscientific research study as science-based clinical research.

 

A 2012 study[6] from the Psychiatria Danubina[7] journal, utilized a similar research design to examine a more established psychological paradigm, Cognitive-Behavioral Therapy (CBT). Researchers from the Department of Psychiatry, at the Medical University of Gdańsk (Poland), studied the effect of CBT treatments on sleep quality and hyperarousal levels in adults diagnosed with primary insomnia. While the research design presents several similar areas of concern, the researches provide a more descriptive and precise methodology, specific and replicable data collection, and a more relevant conclusion.

DIAGNOSTIC DIFFERENCES

The 2013 acupressure and the 2012 CBT study both attempted to examine the effectiveness of their respective therapies in relationship to psychophysiological insomnia[8], the primary type of insomnia and sleep disturbance under care of a psychiatrist or psychologist.

 

Participants in the CBT study were diagnosed by psychologist with primary insomnia, using clinical criteria from the DSM-IV TR[9] as their diagnostic basis. Psychiatrist from the acupressure study instead utilized the ICSD-2 for diagnosing participants. What the DSM-IV TR refers to as primary insomnia, the ICSM-II manual, and the updated DSM (5)[10], refer to the condition as psychophysiological insomnia. The DSM-5 was released after the publication of the CBT study and more closely resembles the ICSM-II. Despite slight differences in terminology and format, the DSM-IV TR diagnostic criteria was essentially the same.

  • A complaint of difficulty in initiating, maintaining sleep or experiencing non-restful sleep for more than one month
  • Significant distress or impairment in functioning during waking hours
  • Sleep disturbances must exclude known biological disruptions, environmental effects, medical conditions, mental illness, or substance use

COGNITIVE BEHAVIORAL THERAPY AND INSOMNIA

Cognitive Behavioral Therapy (CBT)[11], as a psychotherapy, attempts to relieve maladaptive thinking. These negativethought processes may cause behavioral, emotional, or psychosomatic dysfunctions. CBT presents patients with a logic-based therapy: a CBT therapist:

  • assists patients in identifying and assessing thought patterns (cognitions) resulting in the undesired behavior(s)
  • addresses misconceptions, regarding the patient’s thoughts or behaviors
  • provides patients methods to alter their thought patterns in order to modify the desired behavior.

The Gdańsk study employed an insomnia specific CBT treatment developed by Dr. Michael Perlis[12]. Three key aspects of the therapy are:

  1. Sleep Restriction Therapy: the therapist instructs the patient to restrict negative sleep behaviors—such as mid-day napping, and going to bed early—in order to adjust tiredness to the desired time frame
  2. Stimulus Control Instruction: the therapist provides “do’s” and “dont’s” for maintaining restful sleep—the therapist and patient examine behaviors, thought patterns prior to attempting sleep, anxieties and other negative cognitions, determining patient specific conditions that may be disrupting sleep
  3.  Sleep Hygiene Education: the therapist provides customized alterations to patient specific behaviors, attempting  to produce a guide for sleep, while allowing for the patient’s input and adjustment

Using the Perlis method, therapist also teach patients how to recognize and prevent reocurrences. Unlike acupressure, and Eastern “medicine” techniques, CBT has been well established in the literature, and is endorsed by the National Institute for Health[13].

 

The Gdańsk CBT study, when compared to the acupressure study, provided a superior attempt utilizing the same basic research design. The Gdańsk study provided relevant targeted behaviors and precise data collection with corresponding qualitative information. However, the study still shared similar design flaws, and failed to present a clear CBT as the specific cause relieving insomnia symptoms.

  • The researchers provided extensive and precise data points for comparing therapeutic effects. The data collected was relevant to testing the hypothesis, but the chosen research design still suffers from inherently  weak internal validity.
  • The researchers chose a specific mechanism of effect, an insomnia specific CBT treatment developed by Dr. Michael Perlis, but failed to explain specific methods provided in treatment.
  • The study shows a strong correlation between CBT treatment and the relief of insomnia symptoms in participants, but does not provide sufficient data, due to design, to infer CBT as the sole causative factor for the therapeutic effect

AN INTRODUCTION

The Gdańsk study provided a literature review relevant to insomnia and specific to their targeted behaviors. Four behaviors are specified prior to testing the research effectiveness.

  1. Sleep onset latency
  2. Number of sleep awakenings
  3. Sleep Quality
  4. Psychophysiological hyperarousal

The study examined the efficacy of CBT treatment for primary—psychophysiological—insomnia though the four specified targets behaviors, and as a secondary objective, explored differences between persons more and less vulnerable to stressors predicting insomnia.

 

Each targeted behavior of the Gdańsk study was established prior to testing; previous research established these aspects as key factors of psychophysiological insomnia. The researchers provide multiple studies, establishing the four targeted behaviors. DSM provides similar information. By establishing specific points for testing, with established relevance, the researchers prevented issues of data-dredging for significance, a damning weakness of the acupressure study.

 

For comparison: the acupressure study briefly introduced the idea of insomnia, before diving into an exploration of Eastern “medicine”, and how acupuncture and acupressure restore the flow of energy along human body’s meridians (energy channels). The researchers explained a particular point on the body, the HT-7 point according to “tradition” —FYI > not established by any scientific tradition—seems to have a therapeutic effect in patients with disorders of sleep initiation and maintenance. Regardless of the existence of these meridians on the body, specific points, the Sea-Band doesn’t even claim to utilize that point.

 

The study aimed to assess the efficacy and safety of the HT-7 point acupressure system—the Sea-Band?— for treating insomnia in adolescents. They specified the use of a polysomnographic evaluation—without specifying which of the 22 data points they would consider relevant to their specific study, and why those points are relevant.

 

The DSM-IV TR[14] reveals the ineffectiveness of the polysomnography tests in distinguishing persons with insomnia from persons experiencing typical sleep (though the test may show impairments with sleep continuity—specifically sleep onset latency and frequent sleep awakenings).

THE DESIGN

The Gdańsk study recruited 26 individuals, in their early forties—22 women and 4 men. Persons presenting with insomnias other than primary insomnia were excluded from the study. Potential participants evaluated using the Hospital Anxiety and Depression Scale (HADS-M).[15] Individuals with high HADS scores were excluded from the study.

 

A Ford Insomnia Response to Stress Test (FIRST) was employed to test the secondary objective of the study, and separated participants into two groups-one group with a high vulnerability to stressors resulting in insomnia, the other group with a low vulnerability to stressors resulting in insomnia[16].

The study employed the four primary tests to assess sleep quality and hyperarousal associated with insomnia:

  • Athens Insomnia Scale
  • Leeds Sleep Evaluation Questionnaire
  • Sleep Diary
  • Actimetry Test

Treatment consisted of a supervised board certified CBT therapist providing the participants the Perlis CBT program for insomnia. Sessions were 50-minute, weekly, for 8-10 weeks, with one follow-up session at 3 months post-treatment.

RESULTS

The AIS scale was assessed prior to treatment, after treatment, and during the follow-up session. High scores relate to sleep difficulties. The results presented a significant change and a negative trend that continued after treatment, as of the follow-up session.

 

The AIS scale is a self-assessment test, established as an effective means for research and diagnosis of insomnia. It is a holistic assessment, including questions concerning sleep quality—awakenings, induction, duration—as well as, daily functioning and sleepiness.[17]

 

The study used the Hyperarousal Scale to determine hyperarousal levels in the participants. A significant statistical decrease was detected in psychophysiological arousal, as measured by the the Hyperarousal Scale.

 

Hyperarousal—somatic and cognitive arousals, often worrying or ruminating about sleeping or sleep onset—has proven to be a key component disrupting the sleep of persons  with insomnia (Espie et

al. 2006)[18]

 

The Hyperarousal Scale, another self-report assessment, has been established as a valid assessment of increased behaviors and thought patterns in persons with insomnia, when compared with EEG arousal measures.[19]

 

The study also used the Leeds Sleep Evaluation Questionnaire (LSEQ) to evaluate sleep quality, improved quality of falling asleep, and decreased morning awakenings.

 

The LSEQ is another self-report, assessed: a person’s quality of sleep, ability to get to sleep, quality of awakenings from sleep, and tiredness following wakening.[20]

 

The sleep diaries maintained by participants during and after treatment showed a significant decrease in

  • Sleep onset latency—from more than 60 minutes, to nearly 20 minutes
  • Number of sleep awakenings—from an average of 2, to an average of .04
  • Sleep efficiency—77% before treatment, 93% after treatment

While subjective, if effective properly maintained, the sleep diaries provide not just expanded data to assess the process of the the treatment, but a method of self-assessment and potential therapeutic benefit.

 

The actigraphic test night/day ratio, performed over two seven-day periods—one  prior to treatment, and one following treatment—did not show a significant change in the ratio of night/day time (sleep/wake) time.

 

Actigraphic testing has shown to be as effective a test as polysomnographic study, neither have proven to be specifically as an identifier of persons with psychophysiological insomnia.[21][22]

 

Based upon the above findings, the Gdańsk researchers concluded CBT was an effective treatment for primary-psychophysiological-insomnia. Though the above assessments showed no significant relationship between participants with high vulnerability or low vulnerability as determined by the FIRST.

 

The Gdańsk study, like the acupressure study, employed an inherently weak research design. Both studies utilized a one-group pretest-posttest design[13]. A single group—in the Gdańsk study, adults with insomnia—are tested prior to therapy, provided the therapy, and tested after therapy. The Gdańsk study adds a second posttest, as well as multiple points of data throughout the therapy, via the sleep diary.

 

Unlike the acupressure study, the Gdańsk study attempts to balance this issue with these expanded data points. Each test is a relative test of hypothesis, and an established standard test within the fields of psychology and sleep medicine.

 

The Gdańsk study chose the actigraphic test over a polysomnographic test, despite the assertion—non-sequitur assumption?—from the acupressure research team, test results form either test cannot establish a relationship to psychological insomnia symptoms.[23]

 

Regardless of non-significance, the actigraphic test was assessed over seven days, during both the pretest, and the post test. The seven day test provides adjustments for natural variations in sleep. The test performed by the acupressure, on a single day, once before and after treatment, creates too many variables and cannot be an effective measure of sleep patterns.

 

The other test, while qualitative by design, have established a qualitative equivalence, or relevance, in assessing the various qualities in sleep affected by insomnia. While, the acupressure study attempts to express the importance of it’s quantitative test, the Gdańsk  study employed qualitative test that may prove more relevant, especially considering the study explored three distinct, established test providing and provided similar results, at three data-intervals—pretest, posttest, and during the 3 month follow-up. These results, in conjunction with the sleep diaries also assessing the study’s four target behaviors, provide significant data in concluding a relationship between CBT to improved sleep quality and diminished hyperarousal.

 

“Pharmacotherapy remains the most common treatment for insomnia. However, many studies suggest CBT may be a supreme therapeutic approach resulting in better long-term outcome (Morin 2006).”[24]

 

While several studies have shown CBT to be an effective treatment for insomnia[24] and other disorders—such as anxiety—and may be more effective than medicine for some mental illness. It remains difficult to determine whether simply receiving an attentive psychotherapy treatment for some issues are beneficial and CBT specifically. Current evidence shows CBT to be ineffective in persons with medical illnesses—as chronic fatigue syndrome-and certain mental illness—such as severe depression, bipolar and schizophrenia—and substance abuse issues.[26] 

 

The study mentioned using a modified mention of the Perlis treatment. Including specific methods employed during CBT therapy would increase the ability to generalize and replicate the study, and the study’s effects.

 

The Gdańsk study sees the lack of polysomnographic recordings as a serious limitation. However, the lack of a control group and the limited size of the sample provide a greater hit to internal validity. The lack of a control group, and random assignment increase bias for the experimenter and with the test group. The sample, enrolled by the study, hinders external validity and generalization.

 

While these flaws must be considered when considering the relevance of research, the study provided relevant data for CBT treatments of insomnia, in relation to the targeted behaviors.

 

The study clearly defines most methods, treatment and targeted behaviors, providing a basis for future research, and replication—though as mentioned above, a greater description of the methods of CBT would increase the ability to generalize the results.

 

Gdańsk researcher’s concluded the efficacy of the CBT treatment; however, the research design provides too many variables, and prevents causation with any certainty. At best, the research shows a strong relationship—correlation—between CBT treatments and insomnia management.

DISCUSSION

Why do physiological test have a hard time differentiating persons with psychophysiological insomnia from persons with typical, well-adjusted sleep patterns?

 

Does CBT offer an effective therapy, or has the current consensus of effectiveness within psychology/psychiatry provided CBT a better mask than acupressure, alternative therapies, or other psychotherapies?

STAY TUNED! Look for NEW posts every MONDAY! For updates, follow GETPSYCHED@getpsychedblog or on google+!

 

 
[1]An Inaccurate Account of Acupressure’s Effect on Insomnia http://mgn1.me/16oB1fW
[2] Carotenuto, M., et. al. (2013). Acupressure therapy for insomnia in adolescents: a polysomnographic study.Neuropsychiatric Disease and Treatment, 9(1), 157-162. http://europepmc.org/articles/PMC3559075/reload=0;jsessionid=HkcC9YFQkApU1TPB74cz.40
[3] Acupressure http://en.wikipedia.org/wiki/Acupressure
[4] Sleep Disorders http://yoursleep.aasmnet.org/Disorder.aspx?id=42
[5] Logical Fallacy: Argument from Authority http://www.theskepticsguide.org/resources/logical-fallacies?wlfrom=%2Fresources
[6] Gałuszko-Węgielnik M., Jakuszkowiak-Wojten K., Wiglusz M.S., Cubała, W.J., & Landowski J. (2012). The efficacy of cognitive-behavioural therapy (cbt) as related to sleep quality and hyperarousal level in treatment of primary insomnia. Psychiatria Danubina, 24(S1), 51-55.http://www.hdbp.org/psychiatria_danubina/pdf/dnb_vol24_sup1/dnb_vol24_sup1_51.pdf
[7] Psychiatria Danubia http://www.hdbp.org/psychiatria_danubina/
[8] Sleep Disorders http://yoursleep.aasmnet.org/Disorder.aspx?id=42
[9] American Psychiatric Association. (2000). Sleep Disorders. Diagnostic and Statistical Manual of Mental Disorders (4th ed., tex rev.). Washington, DC: Author.
[10] American Psychiatric Association. (2013). Section II: diagnostic criteria and codes, sleep-wake disorders. Diagnostic and Statistical Manual of Mental Disorders (5th ed.). DOI: 10.1176/appi.books.9780890425596.685034
[11] Cognitive Behavioral Therapy http://en.wikipedia.org/wiki/Cognitive_behavioral_therapy
[12]Michael Perlis http://www.med.upenn.edu/bsm/faculty_perlis.html
[13]Insomnia [NIH] http://www.nhlbi.nih.gov/health/health-topics/topics/inso/treatment.html
[14] American Psychiatric Association. (2013). Section II: diagnostic criteria and codes, sleep-wake disorders. Diagnostic and Statistical Manual of Mental Disorders (5th ed.). DOI: 10.1176/appi.books.9780890425596.685034
[15] Hospital Anxiety and Depression Scale http://en.wikipedia.org/wiki/Hospital_Anxiety_and_Depression_Scale
[16] Ford Insomnia Response to Stress Test (First) http://termwiki.com/EN:ford_insomnia_response_to_stress_test_(FIRST)
[17] Athens Insomnia Scale http://www.ncbi.nlm.nih.gov/pubmed/11033374
[18] Espie, C.A., Broomfield, N.M, MacMahon, K.M.A., Macphee, L.M., Taylor, L.M. (2006). The attention–intention–effort pathway in the development of psychophysiologic insomnia: a theoretical review. Sleep Medicine Review, 10(4),215-245.http://www.sciencedirect.com/science/article/pii/S1087079206000219
[19] Pavlova, et al. (2001). Self-reported hyperarousal traits among insomnia patients. Journal of Psychosom Res, 51(2), 435-441.
[20] LSEQ example http://www.nps.org.au/publications/health-professional/nps-radar/2010/may-2010/melatonin/melatonin-web-extra
[21] American Psychiatric Association. (2013). Section II: diagnostic criteria and codes, sleep-wake disorders. Diagnostic and Statistical Manual of Mental Disorders (5th ed.). DOI: 10.1176/appi.books.9780890425596.685034
[22] Polalck C.P., Tyron, W.W., Nagaraja, H., & Dzwoncyk, R. (2001). SLEEP, 24(8), 957-965. http://www.journalsleep.org/Articles/240811.pdf
[23] American Psychiatric Association. (2013). Section II: diagnostic criteria and codes, sleep-wake disorders. Diagnostic and Statistical Manual of Mental Disorders (5th ed.). DOI: 10.1176/appi.books.9780890425596.685034
[24][25] Morin, C.M. (2006): Combined therapeutics for insomnia: should our first approach be behavioral or pharmacological?
SLEEP, 7, S15-19. http://www.ncbi.nlm.nih.gov/pubmed/16702028
[26]Hofmann, S.G., Asnaani, A., et al. (2012). The efficacy of cognitive behavioral therapy: a review of meta-analyses. Cognitive Ther Res, 38(5), 427-440.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584580/
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AN INACCURATE ACCOUNT OF ACUPRESSURE’S EFFECT ON INSOMNIA

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NEUROPSYCHIATRIC PSEUDOSCIENCE ATTEMPTS TO LEGITIMIZE ACUPRESSURE AND THE SEA-BAND TREATMENT

 

Insomnia is a disruptive and sometimes debilitating condition. Nearly 30% of adults report experiencing at least one symptom of insomnia[1]. Though many of us experience situational insomnia to a degree—especially as a grad student—only about 6% of people experience insomnia severe enough to meet clinical criteria.

 

There are several types of sleep disruptions classified as insomnia. Psychological research of insomnia often focuses on psychophysiological insomnia.[2]  To be classified as psychophysiological insomnia, the sleep disruption cannot be due to substance use, mental illness, or medical conditions. Diagnosis by the DSM-5[3] must include dissatisfied sleep and at least one of the following criteria: sleep latency—difficulty initiating sleep; frequent nocturnal waking—difficulty maintaining sleep; prolonged periods of wakefulness; or undesired early waking. The sleep disturbance must also cause significant distress and dysfunction during non-sleep activity, and must occur for at least three nights a week over the course of three months.

 

A new study[4] published in the Journal of Neuropsychiatric Disease and Treatment[5] presents a suspect treatment for psychophysiological insomnia in adolescents. Researchers at the Clinic of Child and Adolescent Neuropsychiatry in Naples, recently concluded acupressure[6] to be an effective therapy for managing insomnia in adolescents.

 

How? Unfortunately, I don’t know how. I have read the article a dozen times, and the science and research design are deeply flawed. 

 

I believe the study intentionally attempted to provide an unsubstantiated legitimacy to acupressure as an alternative therapy[7]—specifically assisting the interests of the manufacturer of the Sea-Band device used within the study. The researchers used pseudo-scientific conventions to convey the pretense of scientifically valid clinical research. 

 

I fail to see how how the authors could present the data in the study as research. It is ill structured, even to infer a loose correlation, let alone conclude significance and effect—especially when considering:

  • The study employed a flawed research design, vague data collection, and data-dredging[8] to infer statistical significance.
  • The researchers did not clearly define the mechanism of effect for the therapy.
  • The study is full of logical fallacies[9], further compromising the internal validity of the study and contributing to reader confusion.

THE STUDY DESIGN

The researchers explicitly described the study as an assessment of the efficacy and safety of an HT-7 point acupressure system when used to treat insomnia in adolescents. Yet, the study more accurately assessed the Sea-Band device, and does not conclusively treat insomnia.

 

The study did not examine or reference any established efficacy of Sea-Band as a treatment for insomnia, nor did it provide evidence for the efficacy of Sea-Band device as an acupressure device.

 

Further, the study inferred—relied on—acupressure as established therapy. Yet it did not provide a clear method of effect for either acupressure or the Sea-Band device.

 

“Insomnia can be treated with medication, herbal therapy, and psychologic or physical therapy. Commonly used medications include hypnotic/sedative drugs, but may have adverse effects, including impairment of memory, drug resistance, dependency, and addiction. Among the nondrug therapies for insomnia, acupressure, a method used for over 5000 years in Eastern medicine, is becoming increasingly popular worldwide.”

 

To establish acupressure as a potential therapy for insomnia, the author referred to a single study[14]. That study reviewed meta-analysis of various studies combining acupuncture, acupressure, and reflexology; it concluded there was no evidence supporting any of these therapies as an effective treatment for insomnia.

 

Even presuming acupressure is a potential therapy, and stimulating the HT-7 point is the mechanism of effect, the author does not give clear cause for the premise that use of the Sea-Band is acupressure. In fact, while providing not further exploration into how they work, the Sea-Band website FAQ[15] states the band exerts pressure and stimulates the P6 acupressure point, not the HT-7.

 

It is also not clear whether the devices were given to subjects with the pretense of improvement, or as a test for therapeutic effect, but the author specifically stated:

“The Sea-Band device was given to the patients in order to improve their symptoms related to difficulty falling asleep.”

This might convey to a potential participant—or an unsuspecting reader of the study—an unwarranted assumption of the established therapeutic ability of the Sea-Band device to diminish insomnia, and may also the confirmation bias of the research team.  

 

Researchers recruited 25 adolescents affected by psychophysiological insomnia. Subjects were caucasian from a middle-class socioeconomic background. Initial screenings and preliminary diagnoses were made by a neuropsychiatrist, utilizing criteria from the International Classification of Sleep Disorders (ICSD-2)[10]—criteria from the ICSD-2 closely resembles the above DSM-5 criteria. 

 

The small sample size and the common locality of the sample subjects might present some concern—and were the only limitations of the study admitted to provided by the researchers—however, the sample size and criteria for diagnosis are not dissimilar to other sleep studies, and seem practical for an initial therapeutic investigation.

 

Subjects must have reported experiencing at least two of the following symptoms for at least two years prior to the study: fragmented sleep, frequent awakenings, early morning awakenings, or feeling tired due to poor sleep quality. They were given two Sea-Bands devices, to be worn bilaterally on the wrist at the Shen Men point on the wrists during normal bedtime hours.

 

Two sets of two polysomnographic sleep studies[11] were performed. The first set established a baseline before acupressure “therapy,” and the second set to establish the effects after six-months of acupressure “therapy.” Researchers did not evaluate the first night of the sleep studies, from each set, in order to remove the first night effect[12] known to produce unrepresentative sleep data.

 

The basic research design of the study is weak, and presents more questions than answers.

The study utilized a one-group pretest-posttest design[13]. A single group—in this case adolescents with insomnia—are tested prior to therapy, provided the therapy, and tested after therapy. This design is generally referred to as a pre-experimental or quasi-experimental design. The internal validity of this type of test is compromised, due to the lack of a control group, and difficulty accounting for the impact of extraneous variables.

 

The addition of a control group—perhaps wearing a device similar in appearance to the Sea-Band—would have strengthen the validity of the research design.

Further, only two data points were used. A more effective study might have examined the subjects for multiple days during the pretest and posttest, and might have utilized sleep journals during the intervening therapeutic period.

 

DATA, DATA, EVERYWHERE

 

The research team collected and analyzed twenty-two separate criteria from sleep studies. Criteria included: Time in bed, total sleep time, sleep latency, percentage of time in specific sleep stages, sleep efficiency percentage (sleep time/time in bed * 100), etc. The team analyzed each data point using an analysis of variance test, and significance at the P value of < 0.05. They found a “significant” change in about half of the values. The significant results included: Increased time in bed, increased total sleep time, and reduced sleep onset latency.

“A strength of the the gold standard polysomnography for assessment of sleep alterations in order to circumvent subjective reporting by patients.”

The data does not support the explicit  hypothesis and relies on non-sequiturs to infer significance.

The researchers data-dredged. There hypothesis was vague, and they did not clearly state what and how they determine a change in sleep difficulty. By examining all 22 categories, the researchers presented a ripe opportunity for false pattern-recognition. This undermines the internal validity of the study—whatever internal validity remained—and severely muddies the conclusions of the study.

 

The researchers presumed the the device lessened sleep difficulties due to significant differences in only 11 of the 22 categories. They completely failed to acknowledge the p-values of criteria not supporting their hypothesis and the variability within their selected sample. Persons with insomnia do not have to experience all the symptoms to meet the clinical threshold—Instead:

  • The study should have provided all clear changes in data values.
  • The researchers should have predetermined data criteria, and established the importance of specific criteria for improving sleep quality.
  • The researchers might have Instead examined only common values experienced by subjects.

The author used a non-sequitur argument to dismiss qualitative data and increase the perceived value of their quantitative data—researchers could have utilized a well designed qualitative survey to determine treatment efficacy, especially considering the initial criteria for diagnosis of insomnia is a dissatisfaction with sleep quality and an impairment of daily function due to lack of sleep. The change in the data provided presumes the therapy manages insomnia, without explaining how the data translates to insomnia relief, or whether subjects experienced a relief from their symptoms

 

CONCLUSIONS

“Acupuncture and acupressure are believed to restore equilibrium. Acupressure involves using the fingers, thumbs, palms, heels of the hand, and elbows to apply pressure and stimulate specific points along the meridians (or energy channels) of the body.”

The study concluded that acupressure could be a “safe, effective, and cost-effective therapy for the management of psychophysiological insomnia.” My conclusion: The researchers cherry picked data. The data’s support of hypothesis is vague and not clearly tested by the parameters of the study. Providing such a definitive conclusion, with such shoddy science, leads me to believe the researchers initiated the study with a pre-existing agenda, and intentional fraud, providing a disservice by further adding to public confusion and concern surrounding psychological research.

 

If a person with insomnia is concerned about the risks associated with sleep-aid medications, alternative therapies, like acupressure, provides a risk free alternative, also free of definitive results. But,

STAY-TUNED — My next post will examine the effectiveness of Cognitive Behavioral Therapy for psychophysiological insomnia.

 

STAY TUNED! Look for NEW posts every MONDAY! For updates, follow GETPSYCHED@getpsychedblog or on google+!

[1] Roth, T. (2007). Insomnia: definition, prevalence, etiology, and consequences. Journal of Clinical Sleep Medicine, 3(5), 7-10. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978319/

[3] American Psychiatric Association. (2013). Section II: diagnostic criteria and codes, sleep-wake disorders.  Diagnostic and Statistical Manual of Mental Disorders (5th ed.). DOI: 10.1176/appi.books.9780890425596.685034

[4] Carotenuto, M., et. al. (2013). Acupressure therapy for insomnia in adolescents: a polysomnographic study. Neuropsychiatric Disease and Treatment, 9(1), 157-162. http://europepmc.org/articles/PMC3559075/reload=0;jsessionid=HkcC9YFQkApU1TPB74cz.40

[5] Journal of Neuropsychiatric Disease and Treatment http://www.dovepress.com/neuropsychiatric-disease-and-treatment-journal

[12] Agnew, H. W., Webb, W. B., & Williams, R. L. (2007). The first night effect: an EEG study of sleep. Psychophysiology, 2(3), 263-266. http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8986.1966.tb02650.x/abstract?

[13]  Sheskin, D. J. (2011). Handbook of Parametric and Nonparametric Statistical Procedures (5th ed.). New York: CRC Press.

[14] Yeung, W.F, et. al. (2011). Acupressure, reflexology, and auricular acupressure for insomnia: A systematic review of randomized controlled trials. Sleep Medicine, 13(8), 971-984. http://www.sleep-journal.com/article/S1389-9457(12)00257-2/abstract

 

 

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EXTRACTING SIGNAL FROM THE NOISE

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The Importance of Replication in Psychological Science [2/2]

THE OCCURRENCE OF REPLICATION

“ONLY 1.07% of published psychology articles were replications!”

replicationRecent accusations of scientific fraud and shoddy methodology increased public scrutiny of psychological research. This scrutiny revitalized awareness within the field. Researchers discussed and debated various solutions, hoping to reduce error and scientific fraud. These discussions frequently pointed to one solution, replication.

I previously introduced a recent study directed by Dr. Matthew Makel: Replications in Psychology Research: How Often Do They Really Occur? Dr. Makel and a team of Duke investigators researched the previously unmeasured prevalence of replication in psychology. He acknowledges the recent public condemnation, and a need to redirect the field towards more rigorous science. Consistently testing research results reveals errors and strengthens procedural rigor. Frequent replication may provide psychology the key course correction needed to reverse public opinion and repair research methods.

The study conducted an exploratory investigation. The team hoped to provide an overview and the starting point for future discussion and direction. The Duke team investigated the entire publication history of 100 psychology journals. The team examined the journals for the total number of replications, and changes in the amount of replication over time. Dr. Makel also looked for factors contributing to successful replications.

The investigation team uncovered an alarmingly low frequency of replication in psychology. They also uncovered a substantial difference in successful reproductions when the replication was conducted by a member of the original research team.

Of the 320,000 articles, only 5,000 articles used a variation of the term replication, about 1.6%. The investigation examined a randomly selected sample of 500 articles using the term. Of those 500, only 68% were actual replications. Dr. Makel adjusted the data with this  new information, it revealed only 1.07% of published psychology articles were replications! While there seems to be an increase in the last ten years, the total number of replication studies was still low, at 1.8%. Dr. Makel believes this low occurrence of replication may indicate psychology actively deters replication.

“A field that replicates its work is rigorous and scientifically sound.”

NOT ALL REPLICATIONS ARE CREATED EQUAL

Like original research, replications must provide proper methodology and an accurate analysis of the data. By expanding the original data, replications assist researchers in recognizing clumps of data perhaps leading to false-positive results. However, replication research is not without its own inherent concerns. An important aspect of replication that the research is conducted by an independent team. The Duke study provides a clear distinction between the success rate of replications involving a a member of the original research team, and  those conducted by completely independent research teams.

Replications involving an overlap of team members from the original research presents increased risk of confirmation bias. The Duke team found 92% of replications with overlapping team members successfully reproduced the findings of the original study. Only 65% of replications by independent research teams confirmed the results of the orignal study. If a key aspect of preventing bias is independent replication, using Dr. Makel’s data, only .49% of psychological studies are independent research replications!

“ONLY .49% of psychological studies are independent research replications!”

Dr. Makel expressed other minor concerns affecting replication. Confirmation bias also affects independent researchers (Moonesinghe, et al. 2007). Researchers may confirm an expected result due to perceived consensus. Further, variations in research resources and researcher capabilities creates concern about replication equivalency, and the precision provided by research replication. However, these concerns due not provide cause to disregard replication. A little bit of replication goes a long way. Improving the frequency of independent replications provides “self-correction” for original research, as well as the replicated research.

THE POSITIVE EFFECTS OF BIAS

Why does a low occurrence replication matter?

Most psychological scientist positively regard replication. Replication seems to be a simple enough concept, and has been valued by all of science as a sort of standard candle, or what Dr. Makel refers to as the scientific “Supreme Court.” Replication expands the original data and examines research methodology. Reproducibility helps research achieve validity, diminishing concerns about false-positive results, and decreasing experimenter and measurement biases. Replication contributes to consensus.

Unfortunately, the field emphasizes a conflicting ideal for original research. Researchers must fill gaps in the literature in order to advance knowledge. Further, Researchers involved in replication are not looked on as advancing knowledge, even though many agree,“a field that replicates its work is rigorous and scientifically sound.”  Even as a graduate student contemplating my theses, I am expected to find a gap in the literature, and develop original research. Just exploring new information ignores the benefit of independent replications. Reproducing or dismissing past results serves the literature by strengthening conclusions or revealing false-positive results. It is like  filling a pot-hole with stone, and failing to pave the cavity with cement. The ideal of originality provides a greater abundance of knowledge, but also generates greater uncertainty.

The low replication rate provides few opportunities to correct false findings, and may explain the high rate of successful research in psychology.

As I discussed in my last post,  the ESP research by Stanford psychologist, Dr.Daryl Blem, exemplifies intentional scientific fraud in contemporary psychology (and exacerbated the current public scrutiny). However, not all fraud is intentional. Psychologist tend to find significance in the research more frequently than any other discipline (Fanelli 2010 and Ioannidis 2005).  A year before the Duke study, an article in the Wall Street Journal explored the difficultly various disciplines experienced in reproducing research results. When replications do occur, they often fail to reproduce results from the original study, which may lead to a file-draw effect, in which researcher will not submit findings for publication in order to maintain the status quo. Scientist are pressured to succeed. Money and recognition flows more freely towards research establishing significance. Further research is needed, but these findings may be indicative of pervasive confirmation bias, supported by Makel’s findings about researcher overlap.

The infograph below displays the amount of published positive findings throughout science. Psychology publishes more studies supporting the tested hypothesis tan any other discipline. (Faneli 2010)

ACCENTUATE THE POSITIVE

CONCLUSIONS

Dr. Makel suggests researching methods for determining what research should be replicated. I believe it is important instead to attempt to alter the attitude of the field towards replication. Any scientific field ignoring replication may enter a state where most published research is false (Ioannidis 2005). Psychology must emerge from the current scrutiny with a more rigorous adherence to empirical research and replication. Psychologist acknowledge the importance of replication, yet maintain an environment overwhelmed by the pressure to publish original research, and expand the literature. Readjustment is needed alongside a redirection of resources. Replication as part of increasing rigorous adherence to the scientific method, will provide a more precise measure of psychological therapies and practices.

Psychological science seems pointed in the right direction and as a discipline is in a unique position. The Duke reported the replication rate doubled since 2000. As a young science psychological science may be more open to a revolutionary redirection emphasizing replication. The historical dismissal of psychological science by more established disciplines, and the recent scrutiny and concerns of scientific fraud, further encourages response and a rigorous redirection. Further, Dr. Makel’s investigation provides the field the initial measurement necessary to encourage and compare future results from replication. His research establishes a baseline and will allow the field to test methods supporting replication, as well as the effectiveness of replication frequency.  By establishing a baseline and an emphasis for research replication, the field establishes a foundation best able to distinguish the signals from an overwhelming cacophony of white noise.

QUESTIONS FOR DISCUSSION?

  • How do the rates of replication vary throughout the different disciplines within the field?
  • Should schools encourage research replication for undergrads and graduate students, as their capstone or thesis?
    • Will this remove the stigma of replication as un-original and failing to advance knowledge?

[TL;DR]

  • There is increased public scrutiny of psychology
  • Dr. Makel investigated 100 years of psychology publications; only 1.07% of  studies were replications
  • Replication is not encouraged in psychology
  • Psychological studies achieve significance more than any other discipline
  • Replication diminishes coincidence and intentional/unintentional error
  • Psychology requires replication to reverse public concern, and recover as a more rigorous scientific endeavor.

 

Interested in more information about replication…?

CHECK OUT THE SCIENCE EXCHANGE REPRODUCIBLITY PROJECT 

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THE IMPORTANCE OF REPLICATION IN PSYCHOLOGICAL SCIENCE [1/2]

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replicationRecent controversies over the integrity of psychological studies provided cause for researchers within the field to evaluate study designs in psychological science. Other disciplines have also expressed concerns over research methods and exaggerated results. While psychology is not alone, psychological science seems centered in the cross-hairs. A team of investigators at Duke University, headed by Dr. Matthew Makel, recently reviewed 100 years of published research in the field of psychology. The study, Replications in Psychology Research: How Often Do They Really Occur?, examined the important role and current issues of replication in psychological science.

Dr. Makel’s study may explain a major factor contributing to the concern of integrity in social science research. Insufficient replication hinders the effectiveness of research and successful validation. His review may also provide a cure, or at least the beginning of a multifaceted therapy. Dr. Makel’s team also provides an avenue for enhancing validation within psychological science by examining the rate of replication, current replication trends, and concerns about successful reproductions. Increased replication may assist the field in dismissing false findings, reducing public confusion, and preventing further scrutiny over design and the entire publication process.

NOTABLE FALSE-FINDINGS

The recent alarming concerns about  psychological research  practices seems warranted. Notable psychologists and peer-reviewed journals in the field have published articles later found to contain false-positive results and exaggerated significance. Some of these articles achieved enhanced public notoriety due to their topics and extraordinary claims. This notoriety may explain the greater scientific and public damnation, as vague and shoddy methodology  brought forth questions of the entire peer-review process in psychology, as subsequent studies failed to reproduce the extraordinary claims of the original research.

Dr. Makel mentions Blem’s 2011 studies of extra sensory perception. Dr. Darly Blem teaches psychology at Cornell University. Dr. Blem produced studies providing evidence for precognition. He claimed his subjects’ choices were affected by future events. His studies were published by a respected peer-reviewed psychology journal, The Journal of Personality and Social Psychology. Controversy erupted soon after the Cornell professor’s flawed research first appeared in the  journal. Many damned a respected journal for publishing para-psychological research. They claimed publishing such psychological pseudoscience in a esteemed peer-reviewed journal increases public confusion over legitimate scientific studies, diminishes the peer-review process, and devalues valid psychological scientific endeavors. It serves as a disservice to psychological science, and the scientific method. It may, however, increase the perceived value of replication within the field.

Three unrelated teams attempted and failed to reproduces Blem’s findings. While there remains cause for concern over several areas of the journal process, encouraging replication remains a key method for self-correction. Does replication provide the ultimate answer for increased awareness of false-positive findings, allowing social scientist to better dismiss studies presenting extraordinary claims and misinterpreting results?

WASH, RINSE, REPLICATE

Dr. Makel presents replication as the “Gold Standard,” or “Supreme Court” of the scientific method. Replication upholds or dismisses results from the original research. Science self-corrects though replication. Reproduction assists new knowledge in gaining acceptance, and  provides a more precise understanding of the information collected. Replication studies attempt to reproduce the results of the original study, either directly or conceptually. Though not without its own  issues, replication strengthens validity and helps the field achieve consensus about findings, while hopefully neutralizing experimenter bias, misinterpreted data, or incorrect design procedures.

Through reproduction, the field is able to direct, or redirect future research, and funding, while strengthening the effective utilization of the research in question. But how much replication occurs, and can we rely on replication to achieve the rigorous design and perceived  integrity required to uphold valid scientific endeavors within the field psychology?

STAY TUNED!

Next post: Monday, October 7 – The Importance of Replication in Psychological Science, Part 2

My next post will examine Makel’s study in greater detail, review replication in other scientific disciplines, and present course corrections necessary to reduce the  uncertainty of research results in psychological science.

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